Caenorhabditis elegans


CELE_F35H12.3, sum-1, F35H12.3
sel-12 encodes a transmembrane domain protein orthologous to presenilins; during gonadal, germline, and vulval development, sel-12 functions, within receiving cells, to positively regulate lin-12 and glp-1 Notch-like signaling pathways; sel-12 presenilin activity and/or levels are likely regulated by the SET/NAP protein sub-family member encoded by spr-2, as mutations in sel-12 are suppressed by mutations in spr-2; spr-2 regulation of sel-12 occurs in a hop-1 presenilin dependent manner.

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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  • Interactors (56)
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