Caenorhabditis elegans
SNX-1
CELE_C05D9.1, vps-5, C05D9.1
snx-1 encodes a PX and BAR domain-containing protein that is the C. elegans ortholog of the Vps5/SNX1 subunit of the core retromer complex; in C. elegans, SNX-1 functions as a component of the retromer complex that, along with RME-8 and HSP-1, regulates retrograde endosome-to-Golgi transport through control of endosomal clathrin dynamics; SNX-1 binds RME-8 in vitro; SNX-1 is expressed in several different tissues, including the intestine, coelomocytes, and hypodermis; SNX-1 localizes to early endosomes, co-localizing with RME-8.
GO Process (8)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- execution phase of apoptosis [IMP]
- intracellular protein transport [IBA]
- meiotic nuclear division [IMP]
- phagolysosome assembly involved in apoptotic cell clearance [IMP]
- phagosome maturation involved in apoptotic cell clearance [IMP]
- phagosome-lysosome fusion involved in apoptotic cell clearance [IGI, IMP]
- retrograde transport, endosome to Golgi [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
45421
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- Interactors 23
- Interactions 41
- Network