Caenorhabditis elegans

SNX-1

CELE_C05D9.1, vps-5, C05D9.1

snx-1 encodes a PX and BAR domain-containing protein that is the C. elegans ortholog of the Vps5/SNX1 subunit of the core retromer complex; in C. elegans, SNX-1 functions as a component of the retromer complex that, along with RME-8 and HSP-1, regulates retrograde endosome-to-Golgi transport through control of endosomal clathrin dynamics; SNX-1 binds RME-8 in vitro; SNX-1 is expressed in several different tissues, including the intestine, coelomocytes, and hypodermis; SNX-1 localizes to early endosomes, co-localizing with RME-8.

GO Process (8)

GO Function (4)

GO Component (4)

Gene Ontology Biological Process

embryo development ending in birth or egg hatching [IMP]

execution phase of apoptosis [IMP]

intracellular protein transport [IBA]

meiotic nuclear division [IMP]

phagolysosome assembly involved in apoptotic cell clearance [IMP]

phagosome maturation involved in apoptotic cell clearance [IMP]

phagosome-lysosome fusion involved in apoptotic cell clearance [IGI, IMP]

retrograde transport, endosome to Golgi [IMP]

Gene Ontology Molecular Function

phosphatidylinositol binding [IDA]
phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
protein binding [IPI]
protein self-association [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

early endosome [IDA]

early phagosome [IDA]

phagocytic vesicle [IDA]

WormBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

45421

6239

Interactors 23
Interactions 42
Network