Caenorhabditis elegans


CELE_C05D9.1, vps-5, C05D9.1
snx-1 encodes a PX and BAR domain-containing protein that is the C. elegans ortholog of the Vps5/SNX1 subunit of the core retromer complex; in C. elegans, SNX-1 functions as a component of the retromer complex that, along with RME-8 and HSP-1, regulates retrograde endosome-to-Golgi transport through control of endosomal clathrin dynamics; SNX-1 binds RME-8 in vitro; SNX-1 is expressed in several different tissues, including the intestine, coelomocytes, and hypodermis; SNX-1 localizes to early endosomes, co-localizing with RME-8.
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  • Interactors 23
  • Interactions 41
  • Network