CELE_AH9.2, AH9.2

crn-4 encodes a DEDD family DNase, a cell death-related nuclease; crn-4 exhibits both DNase and RNase activities; crn-4 is believed to function in a large multinuclease complex, the degradeosome, whose components include the protein products of cps-6, crn-1, crn-5, cpy-13 and other non-nuclease components like wah-1, to promote apoptotic DNA degradation; crn-4 has been shown to bind DNA through its Zn-domain and cleave it through its N-terminal DEDDh domain; crn-4 interacts with crn-5 in protein binding experiments, this interaction has been shown to enhance crn-4 DNAase activity.

45481

6239