Caenorhabditis elegans
KIN-29
CELE_F58H12.1, sns-8, sma-11, F58H12.1
kin-29 encodes a serine/threonine kinase with significant homology in the kinase domain to the AMP-activated protein kinase (AMPK) and SNF1 kinases; the AMP-kinase cascade is activated by cellular stresses that deplete ATP; AMP-kinase is believed to protect the mammalian cell by 'switching off' ATP-consuming pathways like fatty acid synthesis, by phosphorylating key regulatory enzymes, and switching on alternative pathways for ATP generation; kin-29 is involved in regulating the expression of chemosensory receptors and entry into the daur pathway; kin-29 also affects body size via interaction with the Sma/Mab pathway and lifespan, with mutants exhibiting a smaller body size and increased life span; a functional KIN-29-GFP fusion protein is expressed in sensory neurons and many other cell types, and localizes to the cytoplasm; under conditions of cellular stress like heat shock, KIN-29-GFP translocates to the nucleus.
GO Process (12)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- dauer entry [IMP]
- dauer larval development [IGI, IMP]
- detection of chemical stimulus involved in sensory perception [IMP]
- negative regulation of fatty acid biosynthetic process [TAS]
- positive regulation of growth rate [IGI, IMP]
- positive regulation of multicellular organism growth [IGI, IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [ISS]
- regulation of multicellular organism growth [IMP]
- reproduction [IMP]
- response to heat [IEP]
- transforming growth factor beta receptor signaling pathway [IGI]
Gene Ontology Molecular Function
Download Curated Data for this Protein
45518
6239
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- Interactors 3
- Interactions 3
- Network