Caenorhabditis elegans
LIN-18
CELE_C16B8.1, C16B8.1
lin-18 encodes a predicted receptor tyrosine kinase that is a member of the Ryk/Derailed family of tyrosine kinase-related receptors (OMIM:600524, mutations in humans are associated with cleft palate); in C. elegans, LIN-18 is required for establishing the polarity of the secondary vulval cell lineage produced by the P7.p vulval precursor cell; LIN-18 may be a receptor for Wnt-like signaling molecules, and in vulval development appears to function independently of, but in parallel with, LIN-17, a Frizzled-like Wnt receptor, also required for proper orientation of the P7.p lineage; a lin-18 reporter gene is expressed in body wall muscle, neurons, and the developing vulva; in the vulva, expression is detected in P5.p, P6.p, and P7.p and all of their descendants during the L3 and L4 larval stages.
GO Process (8)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
- asymmetric protein localization involved in cell fate determination [IGI, IMP]
- establishment of anatomical structure orientation [IGI, IMP]
- hermaphrodite genitalia development [IGI, IMP]
- morphogenesis of an epithelium [IGI, IMP]
- polarity specification of anterior/posterior axis [IGI, IMP]
- polarity specification of proximal/distal axis [IGI, IMP]
- regulation of asymmetric cell division [IGI, IMP]
- regulation of vulval development [IGI, IMP]
Download Curated Data for this Protein
45614
6239
Switch View:
- Interactors 4
- Interactions 4
- Network