CELE_F20B6.2, F20B6.2

vha-12 encodes an ortholog of subunit B of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-12 is orthologous to human ATP6V1B1 (OMIM:192132, mutated in distal renal tubular acidosis with progressive sensorineural deafness) and ATP6V1B2 (OMIM:606939); VHA-12 and TAG-300/Y110A7A.12 are co-orthologs; VHA-17, like VHA-1 and VHA-12, antagonizes EFF-1-mediated cell fusion in hypodermal cells; VHA-12 is required for necrosis, since mutation of vha-12 suppresses necrotic neurodegeneration, cytoplasmic acidification, and thapsigargin-induced cell death; VHA-12 is predicted to bind ATP as part of a cytosolic VHA-12/VHA-13 heterohexamer, whose ATP hydrolysis drives the V-ATPase rotor; general levels of VHA-12 protein are very low in embryos but increase strongly after hatching.

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