Caenorhabditis elegans
LON-2
CELE_C39E6.1, C39E6.1
lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface.
GO Process (8)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- dendrite development [IMP]
- embryo development ending in birth or egg hatching [IMP]
- locomotion [IMP]
- negative regulation of multicellular organism growth [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [IGI]
- negative regulation of vulval development [IMP]
- nematode larval development [IMP]
- positive regulation of multicellular organism growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
45685
6239
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- Interactors 2
- Interactions 2
- Network