CELE_C54H2.5, SURF-4, C54H2.5

sft-4 encodes an integral membrane protein orthologous to Saccharomyces cerevisiae endoplasmic reticulum (ER)-to-Golgi cargo receptor Erv29p and mouse Surfeit-4 (Surf-4); by homology, SFT-4 is predicted to function as a cargo receptor that selectively transports proteins in COPII vesicles from the ER to the cis-Golgi; SFT-4 activity is required for larval development and for normal down regulation of the LET-23 EGF receptor in the secondary vulval cell lineages; an SFT-4::GFP reporter fusion localizes to the perinuclear region of the cytoplasm, consistent with localization to the endoplasmic reticulum.

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