Caenorhabditis elegans
SFT-4
CELE_C54H2.5, SURF-4, C54H2.5
sft-4 encodes an integral membrane protein orthologous to Saccharomyces cerevisiae endoplasmic reticulum (ER)-to-Golgi cargo receptor Erv29p and mouse Surfeit-4 (Surf-4); by homology, SFT-4 is predicted to function as a cargo receptor that selectively transports proteins in COPII vesicles from the ER to the cis-Golgi; SFT-4 activity is required for larval development and for normal down regulation of the LET-23 EGF receptor in the secondary vulval cell lineages; an SFT-4::GFP reporter fusion localizes to the perinuclear region of the cytoplasm, consistent with localization to the endoplasmic reticulum.
GO Process (10)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- lipid storage [IMP]
- locomotion [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [IGI]
- negative regulation of vulval development [IGI]
- nematode larval development [IMP]
- positive regulation of cellular protein catabolic process [IMP]
- reproduction [IMP]
- secretion by cell [IMP]
Gene Ontology Cellular Component
Download Curated Data for this Protein
45776
6239
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- Interactors 7
- Interactions 9
- Network