CELE_F48E3.3, F48E3.3

uggt-1 encodes one of two C. elegans homologs of UDP-Glc:glycoprotein glucosyltransferase (UGGT), an endoplasmic reticulum enzyme involved in quality control of glycoprotein folding; expression of uggt-1 in S. pombe cells lacking functional UGGT activity indicates that UGGT-1 displays UDP-Glc:glycoprotein glucosyltransferase activity; loss of uggt-1 activity via RNAi results in larval developmental delay and a shortened lifespan; uggt-1 is expressed throughout larval development, with peak levels seen at the L2/L3 stages, and uggt-1 expression is upregulated in an ire-1-dependent manner in response to endoplasmic reticulum stress; a uggt-1::gfp promoter fusion is expressed in the nervous system, including the amphid and phasmid neurons, the nerve ring, and the dorsal and ventral nerve cords.

45931

6239