Caenorhabditis elegans

APY-1

CELE_F08C6.6, F08C6.6
apy-1 encodes a membrane-bound uridine diphosphatase (UDPase, endo-apyrase) orthologous to human CANT1 and paralogous to ZK563.7; APY-1 is required for repression of the unfolded protein response of stressed endoplasmic reticulum (ER), for normally organized pharynx and thin muscle fibers in adults, and for normally high fertility, rapid growth, and long lifespan; apy-1 is transcriptionally activated by tunicamycin, 6% EtOH, or excess heat (25 degrees C), each of which stresses the ER, and this activation requires both ATF-6 and IRE-1; APY-1 can hydrolyze either UDP or GDP, but has more activity with UDP.

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
Download 3 Published Interactions For This Protein
45943
6239
  • Stats & Options
Switch View:
  • Interactors (3)
  • Interactions (3)
  • Network