CELE_C24A3.6, twk-2, mah-2, unc-110, C24A3.6

twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis; as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels; TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel; TWK-18 is expressed in body wall muscle.

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