Caenorhabditis elegans

GPA-12

CELE_F18G5.3, F18G5.3

gpa-12 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is orthologous to members of the mammalian Galpha G12/G13 family; GPA-12 activity is required for antifungal innate immunity and genetic analyses indicate that GPA-12 functions upstream of phospholipase Cs PLC-3 and EGL-8 as well as the TPA-1 protein kinase C in this process; genetic analyses also suggest that gpa-12 functions upstream of tpa-1 in pathways that regulated feeding and growth; gpa-12 is expressed in the pharynx and in the hypodermis.

GO Process (9)

GO Function (4)

GO Component (2)

Gene Ontology Biological Process

Rho protein signal transduction [IBA]

adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]

embryo development ending in birth or egg hatching [IMP]

locomotion [IMP]

mechanosensory behavior [IMP]

oogenesis [IMP]

oviposition [IMP]

response to mechanical stimulus [IMP]

sensory perception of mechanical stimulus [IMP]

Gene Ontology Molecular Function

D5 dopamine receptor binding [IBA]
G-protein beta/gamma-subunit complex binding [IBA]
GTPase activity [IBA]
signal transducer activity [IBA]

Gene Ontology Cellular Component

brush border membrane [IBA]

heterotrimeric G-protein complex [IBA]

WormBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

46073

6239

Interactors 1
Interactions 2
Network