Caenorhabditis elegans

APA-2

CELE_T20B5.1, apt-4, T20B5.1

apa-2 encodes an adaptin: specifically, it encodes an ortholog of the alpha subunit of adaptor protein complex 2 (AP2); loss of apa-2 activity via RNAi results in defects in receptor-mediated yolk endocytosis and thus, embryonic lethality.

GO Process (4)

GO Function (3)

GO Component (3)

Gene Ontology Biological Process

embryo development ending in birth or egg hatching [IMP]

locomotion [IMP]

protein localization [IMP]

receptor-mediated endocytosis [IMP]

Gene Ontology Molecular Function

GTPase activating protein binding [IPI]
protein C-terminus binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

clathrin-coated endocytic vesicle [IDA]

endocytic vesicle [IDA]

plasma membrane [IDA]

WormBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

46079

6239

Interactors 19
Interactions 21
Network

Result Summary

APA-2

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTPase activating protein binding [IPI]protein C-terminus binding [IPI]protein binding [IPI]

Gene Ontology Cellular Component

GTPase activating protein binding [IPI]
protein C-terminus binding [IPI]
protein binding [IPI]