CELE_C17G1.7, C17G1.7

cysl-1 encodes a homolog of sulfhydrylases/cysteine synthases; CYSL-1 functions in neurons to transduce signals from H2S (hydrogen sulfide), which accumulates during hypoxia, to the EGL-9 proline hydroxylase to regulate O2-dependent behavioral plasticity in C. elegans via neuronal activation of the HIF-1 hypoxia-inducible transcription factor.; specifically, CYSL-1 physically interacts with EGL-9 in an H2S-dependent manner to sequester EGL-9 and relieve its inhibitory effect on HIF-1; a CYSL-1::GFP reporter fusion is expressed in the AVM sensory neuron, the BDU interneurons, and the pharyngeal I1 interneurons and M2 motor neurons, as well as in body wall muscles, hypodermis, and intestine; in vitro enzymatic assays and bioinformatics analyses suggest that CYSL-1 does not function as a cysteine synthase in vivo, but instead functions as a signaling molecule to transduce information about the environmental O2 level.

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