Caenorhabditis elegans
ELT-2
CELE_C33D3.1, GATA, C33D3.1
elt-2 encodes a GATA-type transcription factor most similar to the vertebrate GATA4-6 transcription factors required for cardiac and endoderm development (OMIM:601656, 600576); in C. elegans, ELT-2 is required redundantly with ELT-7 for initiating and maintaining terminal differentiation of the intestine and for regulating the intestinal innate immune respone; ELT-2 is expressed solely in the intestine, beginning embryonically at the 2E-cell stage and continuing in all intestinal cells throughout the life of the animal; in the regulatory hierarchy controlling endoderm development, ELT-2 lies downstream of the maternal regulators SKN-1 and POP-1 and the embryonic GATA factors MED-1/-2, and END-1/-3; in turn, ELT-2, along with ELT-7, likely regulates transcription of a number of intestine-specific terminal differentiation genes such as ges-1, ifb-2, pha-4, as well as genes involved in the intestinal innate immune response; ELT-2 also positively autoregulates, presumably to ensure maintenance of intestinal differentiation.
GO Process (15)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- defense response [IMP]
- defense response to Gram-negative bacterium [IEP, IMP]
- determination of adult lifespan [IMP]
- digestion [IMP]
- endoderm development [IMP]
- gene expression [IMP]
- innate immune response [IMP]
- locomotion [IMP]
- nematode larval development [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium [IMP]
- regulation of epithelial cell differentiation [IMP]
- reproduction [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Download Curated Data for this Protein
46163
6239
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- Interactors 18
- Interactions 19
- Network