Caenorhabditis elegans

SYD-2

CELE_F59F5.6, sad-2, F59F5.6
syd-2 encodes alpha-liprin, a member of the liprin family of proteins that interact with LAR (leukocyte common antigen related)-type receptor tyrosine phosphatases (RPTPs) to facilitate clustering of RPTPs to focal adhesions; SYD-2 is required for establishing normal presynaptic density, and is expressed in all neurons and muscles; SYD-2 is required cell autonomously in neurons for differentiation of presynaptic active zones, where SYD-2 is localized; the SYD-2 liprin homology domain 1 (LH1) self-associates in vitro, suggesting that SYD-2 self-assembly contributes to its role in presynaptic assembly in vivo.

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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  • Interactors (3)
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