CELE_K09C8.5, K09C8.5

pxn-2 encodes a member of the peroxidasin family of extracellular peroxidases containing several LLRs, two of four Ig domains and a heme peroxidase catalytic domain, PXN-2 is closely related to human PXDN and PXDNL (OMIM: 605158); PXN-2 function becomes critical soon after the twofold stage of epidermal elongation in embryos; pxn-2 mutants display defects in late stages of epidermal elongation, in muscle and epidermal muscle attachments, in vulval muscle attachment and in morphology of adult pharynx; PXN-2 supports a role in basement membrane function and in neuronal development, PXN-2 acts in selective axon guidance decisions but not essential for axon growth; PXN-2 inhibits adult axon regrowth after injury; PXN-1 acts antagonistically to PXN-2; PXN-2 expressed in differentiated epidermal cell throughout embryonic, larval and adult development, in vulval muscles and a few neurons, in longitudinal striations adjacent to the body wall muscle quadrant close to endogenous basement membrane components.

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