CELE_R08B4.2, sns-10, R08B4.2

alr-1 encodes a homeodomain transcription factor orthologous to aristaless/human Arx; alr-1 regulates the development of sensory neurons in the head and GABAergic motor neurons; ALR-1 affects touch receptor neuron (TRN) fate by acting as a transcriptional activator and is required selectively for TRN gene expression; alr-1 expression in TRNs depends on MEC-3; ALR-1 ensures TRN differentiation by providing a second positive feedback circuit to maintain mec-3 expression; loss of alr-1 produces variable touch sensation; alr-1 increases mec-3 expression by restricting mec-3 expression variability; alr-1 activity is needed throughout larval development; alr-1 is expressed in the ALM, PLM, and AVM TRNs, but not in the nucleus of PVM throughout all larval development.

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