Caenorhabditis elegans
HST-2
CELE_C34F6.4, C34F6.4
hst-2 encodes the C. elegans ortholog of the heparan sulfate modifying enzyme 2O-sulfotransferase; by homology, HST-2 is predicted to function in heparan sulfate biosynthesis by catalyzing the chain-modifying sulfation of the C2 hydroxyl group of hexuronic acid; during development, hst-2 activity is required for normal body size, cell migration, and nervous system development; an hst-2::gfp reporter fusion is first expressed in embryos, continuing on through adulthood; expression is detected in many tissues, including the pharynx, hypodermis, muscles, vulva, and distal tip cells (DTCs) of the somatic gonad.
GO Process (8)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- cellular homeostasis [IMP]
- dendrite development [IMP]
- heparan sulfate proteoglycan biosynthetic process, enzymatic modification [IDA, IMP]
- inductive cell migration [IMP]
- oviposition [IMP]
- positive regulation of multicellular organism growth [IGI, IMP]
- regulation of axon guidance [IMP]
- regulation of cell migration [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download 1 Published Interactions For This Protein
46219
6239
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- Interactors (1)
- Interactions (1)
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