CELE_F08G12.4, F08G12.4

vhl-1 is orthologous to the mammalian von Hippel-Landau tumor suppressor VHL, which is a cullin E3 ubiquitin ligase; vhl-1 promotes the ubiquitination and degradation of the hif-1 hypoxic response transcription factor; vhl-1 and hif-1 act to modulate life span and proteotoxicity, vhl-1 mutants live longer compared to wild-type, by a mechanism separate from dietary restriction and insulin signaling; vhl-1 may also have a hif-1 independent function related to the extracellular matrix.

46231

6239