Caenorhabditis elegans


CELE_ZK455.1, gei-22, ZK455.1
aco-1 encodes an aconitase that is homologous to mammalian iron regulatory protein-1 (IRP1); aco-1 activity is required for normal brood sizes and, under iron stress conditions, for normal lifespan and L4-to-adult growth rates; ACO-1 physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; aco-1 mRNA levels appear to decrease in response to iron treatment; an ACO-1::GFP fusion protein exhibits cytosolic expression in the hypodermal seam cells and the intestine.
GO Process (2)
GO Function (2)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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  • Interactors (2)
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