Caenorhabditis elegans
HPL-1
CELE_K08H2.6, K08H2.6
hpl-1 encodes one of two C. elegans heterochromatin protein 1 (HP1) homologs; loss of hpl-1 activity alone results in no obvious defects, but animals doubly mutant for hpl-1 and hpl-2 have defects in larval, somatic gonad and germline development; in addition, hpl-1 functions redundantly with hpl-2 and lin-13 in vulval development; rescuing HPL-1::GFP fusion proteins are expressed in nuclei throughout the life cycle, beginning at approximately the 50-cell stage of embryogenesis and continuing through larval and adult stages; expression is observed in most, but not all, cells and is particularly strong in head and tail hypodermal and neuronal nuclei; in nuclei, HPL-1::GFP is seen in foci that do not significantly overlap with those of HPL-2.
GO Process (10)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- apoptotic process [IMP]
- germ cell development [IGI]
- gonad development [IGI]
- negative regulation of Ras protein signal transduction [IGI]
- negative regulation of vulval development [IGI]
- nematode larval development [IGI, IMP]
- positive regulation of growth rate [IGI]
- regulation of cell differentiation [IGI]
- reproduction [IGI, IMP]
- vulval development [IMP]
Gene Ontology Cellular Component
Download Curated Data for this Protein
46353
6239
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- Interactors 19
- Interactions 21
- Network