CELE_ZK678.1, lin-15, ZK678.1

lin-15A encodes a novel protein that contains a THAP zinc-finger-like (C2CH) motif; LIN-15A activity is required non-cell autonomously to negatively regulate vulval development; genetic analysis indicates that lin-15A, a class A synMuv gene, functions upstream of the LIN-3 EGF and the LET-23 EGFR and redundantly with class B synMuv genes such as lin-15B and lin-35 Rb and class C synMuv genes such as trr-1 and mys-1 to regulate vulval development; genetic mosaic analysis suggests that, in regulating vulval development, LIN-15A functions outside of the six vulval precursor cells P(3-8).p, likely acting instead in the surrounding hypodermal tissue; LIN-15A is a broadly expressed nuclear protein whose normal expression depends upon LIN-56, an additional THAP motif-containing protein, with which LIN-15A physically interacts.

46555

6239