STAM2, a new member of the STAM family, binding to the Janus kinases.
We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM. STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c-myc induction mediated by IL-2 and GM-CSF. Co-expression of the SH3 ... deletion mutants of STAM1 and STAM2 induces an additive effect on suppressing DNA synthesis upon stimulation with IL-2 and GM-CSF, suggesting that STAM1 and STAM2 exhibit compensatory effects on the signaling pathways downstream of Jak2 and Jak3 upon stimulation with GM-SCF and IL-2, respectively.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Animals, Binding Sites, Cell Line, Cloning, Molecular, DNA, Endosomal Sorting Complexes Required for Transport, Gene Expression Profiling, Genes, Dominant, Genes, myc, Granulocyte-Macrophage Colony-Stimulating Factor, Growth Substances, Humans, Interleukin-2, Janus Kinase 2, Janus Kinase 3, Molecular Sequence Data, Multigene Family, Phosphoproteins, Phosphorylation, Phosphotyrosine, Protein Binding, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Sequence Deletion, Signal Transduction, Substrate Specificity, Transcriptional Activation, src Homology Domains
Adaptor Proteins, Signal Transducing, Animals, Binding Sites, Cell Line, Cloning, Molecular, DNA, Endosomal Sorting Complexes Required for Transport, Gene Expression Profiling, Genes, Dominant, Genes, myc, Granulocyte-Macrophage Colony-Stimulating Factor, Growth Substances, Humans, Interleukin-2, Janus Kinase 2, Janus Kinase 3, Molecular Sequence Data, Multigene Family, Phosphoproteins, Phosphorylation, Phosphotyrosine, Protein Binding, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Sequence Deletion, Signal Transduction, Substrate Specificity, Transcriptional Activation, src Homology Domains
FEBS Lett.
Date: Jul. 14, 2000
PubMed ID: 10899310
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