CELE_F11C7.5, sel-14, F11C7.5

osm-11 encodes a protein required for normal osmosensation, osmotic resistance, and defecation rhythm, and for fully normal growth rate; OSM-11 has no clear orthologs outside of nematodes, but is paralogous to DOS-1, OSM-7, and K02F3.7, has a predicted signal sequence with 12 conserved cysteine residues, and may be secreted; osm-11 mutants have abnormally high levels of internal glycerol, defective osmotic avoidance, and slowed defecation rhythms characteristic of worms under chronic osmotic stress; osm-11 mutants are also somewhat scrawny and slow-growing; osm-11(RNAi) animals show constitutive gpdh-1 transcription.

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