STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction.

We previously identified a putative signal transducing adaptor molecule, named STAM, that contains an Src homology 3 (SH3) domain and immunoreceptor tyrosine-based activation motif (ITAM). In this report, we demonstrate the functional significance of STAM in cytokine-mediated signal transduction. STAM is associated with Jak3 and Jak2 tyrosine kinases via its ...
ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively. An SH3 deletion mutant of STAM confers a dominant-negative effect on DNA synthesis mediated by IL-2 and GM-CSF. Furthermore, the wild-type STAM, but not STAM mutants deleted of SH3 and ITAM, significantly enhances c-myc induction mediated by IL-2 and GM-CSF. These results strongly implicate STAM in the signaling pathways for cell growth and c-myc induction immediately downstream of the Jaks associated with the cytokine receptors.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Animals, Cell Division, DNA, Endosomal Sorting Complexes Required for Transport, Gene Expression Regulation, Genes, myc, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Interleukin-2, Janus Kinase 2, Janus Kinase 3, Mice, Mutation, Phosphoproteins, Phosphorylation, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Receptors, Interleukin-2, Signal Transduction, Transfection, Tumor Cells, Cultured, Tyrosine, src Homology Domains
Immunity
Date: Apr. 01, 1997
Download Curated Data For This Publication
4674
Switch View:
  • Interactions 3