IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family ... member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Antigens, Differentiation, Carrier Proteins, Cell Line, Drosophila Proteins, Humans, Interleukin-1, Interleukin-1 Receptor-Associated Kinases, Molecular Sequence Data, Myeloid Differentiation Factor 88, NF-kappa B, Protein Kinases, Protein-Serine-Threonine Kinases, Proteins, Receptors, Immunologic, Receptors, Interleukin-1, Sequence Alignment, Sequence Homology, Amino Acid, Signal Transduction, TNF Receptor-Associated Factor 6, Transfection
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Antigens, Differentiation, Carrier Proteins, Cell Line, Drosophila Proteins, Humans, Interleukin-1, Interleukin-1 Receptor-Associated Kinases, Molecular Sequence Data, Myeloid Differentiation Factor 88, NF-kappa B, Protein Kinases, Protein-Serine-Threonine Kinases, Proteins, Receptors, Immunologic, Receptors, Interleukin-1, Sequence Alignment, Sequence Homology, Amino Acid, Signal Transduction, TNF Receptor-Associated Factor 6, Transfection
Science
Date: Nov. 28, 1997
PubMed ID: 9374458
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