CELE_C06A6.3, C06A6.3

mvb-12 encodes a protein containing a domain of unknown function (DUF2464) that is the metazoan homolog of Saccharomyces cerevisiae Mvb12p, a member of the endosomal sorting ESCRT-I complex that functions in endosomal sorting of mono-ubiquitinated membrane proteins; in C. elegans, MVB-12 is a non-essential component of the ESCRT-I complex (essential members are VPS-28, VPS-37, and TSG-101) that affects the rate at which cell surface receptors are degraded and hence, the rate at which their activity is downregulated; an MVB-12::GFP fusion protein localizes to the cytosol and to endosomal membranes.

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