CELE_C09G12.9, C09G12.9

tsg-101 encodes the C. elegans ortholog of S. cerevisiae vacuolar protein sorting protein Vps23p and human TUMOR SUSCEPTIBILITY GENE 101 (TSG101; OMIM:601387), mutations in which are associated with several types of cancer and with varying responses to HIV infection; TSG-101 is an essential component of the C. elegans ESCRT-1 (Endosomal Sorting Complex Required for Transport, other members include VPS-28, VPS-37, and MVB-12) that is required for cell surface receptor degradation via the multivesicular body sorting pathway and hence, downregulation of receptor activity.

47326

6239