Caenorhabditis elegans
TSG-101
CELE_C09G12.9, C09G12.9
tsg-101 encodes the C. elegans ortholog of S. cerevisiae vacuolar protein sorting protein Vps23p and human TUMOR SUSCEPTIBILITY GENE 101 (TSG101; OMIM:601387), mutations in which are associated with several types of cancer and with varying responses to HIV infection; TSG-101 is an essential component of the C. elegans ESCRT-1 (Endosomal Sorting Complex Required for Transport, other members include VPS-28, VPS-37, and MVB-12) that is required for cell surface receptor degradation via the multivesicular body sorting pathway and hence, downregulation of receptor activity.
GO Process (6)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
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- Interactors 13
- Interactions 20
- Network