CELE_C16C10.5, C16C10.5

rnf-121 encodes a RING finger E3 ubiquitin ligase; RNF-121 appears to function in the endoplasmic reticulum-associated degradation (ERAD) pathway downstream of PEK-1; RNF-121 exhibits E3 ubiquitin-protein ligase activity in vitro and in vivo regulates levels of the PAT-3 beta integrin subunit which is an RNF-121 substrate; RNF-121 may thus regulate cell adhesion through control of PAT-3 levels, consistent with gonad and germline defects seen upon RNF-121 overexpression; RNF-121 is required for distal tip cell migration (DTC) and genetic interactions suggest that RNF-121 functions at least partially in parallel with the coiled-coil domain protein CCDC-55 and the E3 ubiquitin ligase RNF-5 to regulate DTC migration; RNF-121 is expressed in the hypodermis, including the seam cells, the vulva, uterus, spermatheca, sheath cells, and distal tip cells; RNF-121 localizes to membranes of the endoplasmic reticulum, the sarcoplasmic reticulum, and the Golgi.

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