CELE_C24H11.3, C24H11.3

tbx-38 encodes a T box transcription factor; during embryonic development, tbx-38 functions redundantly with tbx-37 to effect Notch-mediated pharyngeal mesoderm induction in descendants of the ABa blastomere; in addition, tbx-38 and tbx-37 are required for proper cell fate specification of other ABa descendants, such as those that give rise to hypodermal tissue; TBX-38 expression appears to be limited to the 8 ABa descendents at the 24-cell stage of embryogenesis, with expression diminishing markedly during the next cell cycle; negative regulation of TBX-38 expression in ABp descendants depends upon Notch signaling, while negative regulation of expression in EMS descendents is likely controlled, in part, by ref-1 and unc-37, which encode bHLH and Groucho-like proteins, respectively.

47701

6239