Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.

Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association ...
with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Anoikis, Apoptosis Regulatory Proteins, Calmodulin-Binding Proteins, Carrier Proteins, Cell Line, Cytoskeleton, Drosophila Proteins, Dyneins, Gene Expression Profiling, Humans, Membrane Proteins, Mice, Molecular Motor Proteins, Molecular Sequence Data, Mutation, Myosin Type V, Neoplasm Proteins, Nerve Tissue Proteins, Protein Binding, Protein Structure, Tertiary, Protein Transport, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, RNA, Messenger, Transfection, Two-Hybrid System Techniques
Science
Date: Sep. 07, 2001
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