Caenorhabditis elegans

GRD-12

CELE_F02D8.2, F02D8.2
grd-12 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity proline-rich domain, and a C-terminal Ground domain; GRD-12 is expressed in intestine, rectal epithelium, undefined head and tail cells, vulva, and hypodermis; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-12 is required for normal growth to full size, locomotion, and vulval morphogenesis; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
GO Process (3)
GO Function (0)
GO Component (0)

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
Download 2 Published Interactions For This Protein
48879
6239
  • Stats & Options
Switch View:
  • Interactors (2)
  • Interactions (2)
  • Network