An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
Amyloid-beta is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB immunoprecipitates with amyloid-beta, and when ... cell cultures are exposed to amyloid-beta, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-beta on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-beta, ERAB may therefore contribute to the neuronal dysfunction associated with Alzheimer's disease.
Mesh Terms:
3-Hydroxyacyl CoA Dehydrogenases, Alzheimer Disease, Amino Acid Sequence, Amyloid beta-Protein, Animals, Brain, COS Cells, Carrier Proteins, Cloning, Molecular, Hela Cells, Humans, Hydroxysteroid Dehydrogenases, Molecular Sequence Data, Protein Binding, Recombinant Fusion Proteins, Transfection
3-Hydroxyacyl CoA Dehydrogenases, Alzheimer Disease, Amino Acid Sequence, Amyloid beta-Protein, Animals, Brain, COS Cells, Carrier Proteins, Cloning, Molecular, Hela Cells, Humans, Hydroxysteroid Dehydrogenases, Molecular Sequence Data, Protein Binding, Recombinant Fusion Proteins, Transfection
Nature
Date: Oct. 16, 1997
PubMed ID: 9338779
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