Caenorhabditis elegans


CELE_F42G10.2, F42G10.2
mkk-4 encodes a MAP (mitogen-activated protein) kinase kinase that is a member of the MKK4 family of MAPKK's; MKK-4 activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology; in regulating presynaptic organization, MKK-4 acts upstream of PMK-3/MAPK and downstream of DLK-1/MAPKKK, whose levels are negatively regulated by the RPM-1 ubiquitin ligase; a functional MKK-4::GFP fusion protein is expressed in the cytoplasm of many neurons as well as in other cell types, including the pharyngeal muscles.
GO Process (3)
GO Function (1)
GO Component (1)

Gene Ontology Cellular Component

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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  • Interactors (6)
  • Interactions (6)
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