CELE_F43G9.11, F43G9.11

ces-1 encodes a C2H2-type zinc finger transcription factor that is a member of the Snail family of proteins that includes Drosophila Scratch, Snail, and Slug, and human SNAIL and SLUG; during development, CES-1 functions as a transcriptional repressor that blocks programmed cell death in specific neurons by inhibiting expression of the cell-death activator EGL-1; in addition, CES-1 functions to regulate asymmetric cell division and mitotic spindle orientation in the NSM lineage in which it also plays a role in regulating apoptosis; in regulating EGL-1 expression, CES-1 appears to antagonize the transcriptional activity of the bHLH proteins, HLH-2 and HLH-3; genetic studies indicate that ces-1 transcription is negatively regulated by DNJ-11 and by the bZIP transcription factor CES-2, which can bind CES-1 upstream sequences in vitro and thus may directly regulate CES-1 transcription in vivo.

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