CELE_R01H10.6, R01H10.6

bbs-5 encodes a novel protein that is the C. elegans ortholog of human BBS5; bbs-5 is required for the proper regulation of insulin secretion; bbs-5, bbs-1, bbs-8 and bbs-9 mutants along with ciliary phenotypes show an increased secretion of insulin, biogenic amines and neuropeptides which requires the Rab27/AEX-6 dense-core vesicle exocytosis machinery; a BBS-5::GFP reporter protein is expressed exclusively in ciliated neurons, where it localizes to the ciliary base; consistent with the presence of an X box in the bbs-5 5' UTR, bbs-5 expression is positively regulated by daf-19, a RFX-transcription factor.

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