CELE_R07G3.9, R07G3.9

oig-4 encodes a protein containing a single immunoglobulin domain; OIG-4 is expressed by body wall muscle cells and secreted into the extracellular space where it interacts with, stabilizes, and properly localizes a complex containing levamisole-sensitive acetylcholine receptors (L-AChRs) and the LEV-9 and LEV-10 extracellular and transmembrane, respectively, scaffolding proteins; OIG-4 requires L-AChRs to localize to the synapse, but can partially localize to synaptic regions independently of LEV-9 and LEV-10, suggesting that it could play a role in linking local synaptic cues to clustering of the L-AChR complex; OIG-4 is also expressed in the pm6 pharyngeal muscle and four head neurons.

532021

6239