CELE_Y51H1A.4, Y51H1A.4

ing-3 encodes a plant homeodomain-containing protein closely related to human ING3 (Inhibitor of Growth 3, OMIM:607493), mutations in which have been associated with head and neck cancers; genetic analysis indicates that, in the germline, ING-3 functions with CEP-1/p53 to effect germ cell apoptosis in response to gamma irradiation; in addition, ING-3 activity also appears to be required for fully normal locomotion; ING-3 is widely expressed from embryogenesis through adulthood and co-localizes with chromatin in both germ cells and somatic tissues.

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