CELE_K10B3.9, K10B3.9

mai-1 is homologous to mitochondrial intrinsic ATPase inhibitor protein (IF(1)), which blocks reverse action (ATP hydrolysis) by F(0)F(1)-ATPase when its (normally required) proton gradient is lost; MAI-1 lacks an obvious mitochondrial import signal at its N-terminus, and is not transported to yeast mitochondria; MAI-1 may be cytosolic in vivo, regulating cytosolic ATPase(s); MAI-1 can inhibit yeast F(0)F(1)-ATPase, but this inhibition is pH-independent; MAI-1's tertiary structure is dominated by beta-strands and random loops; mai-1 exists as the upstream gene in an operon with gpd-2 and gpd-3.

532550

6239