Caenorhabditis elegans


CELE_T07C4.8, T07C4.8
ced-9 encodes the sole C. elegans homolog of the mammalian cell-death inhibitor Bcl-2; during development, ced-9 activity is essential for preventing cells from undergoing programmed cell death; ced-9 also appears to have proapoptotic activity; CED-9 functions by binding and repressing the activity of CED-4, a protein similar to human APAF-1 and positive regulator of CED-3 caspase activity; CED-9 localizes to the mitochondrial outer membrane, although this localization is not essential for CED-9 to regulate apoptosis.

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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  • Interactors (5)
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