Caenorhabditis elegans
PME-2
CELE_E02H1.4, E02H1.4
pme-2 encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP2 (OMIM:607725); PME-2 has a predicted C-terminal catalytic domain; PME-2 has PARP activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PME-1 is likely to be required in vivo for repairing broken DNA.
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
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533285
6239
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- Interactors 4
- Interactions 4
- Network