CELE_T25F10.5, olrn-2, T25F10.5

bbs-8 encodes a tetratricopeptide repeat (TPR)-containing protein that is orthologous to the human Bardet-Biedl syndrome protein, BBS8; in C. elegans, bbs-8 activity is required for cilia biogenesis and function; accordingly, bbs-8 mutant animals display odorant chemotaxis defects and exhibit both aberrant motility and abnormal localization of at least two intraflagellar transport (IFT) protein markers; bbs-8 is also required for the proper regulation of insulin secretion; bbs-8, bbs-5, bbs-1, and bbs-9 mutants along with ciliary phenotypes show an increased secretion of insulin, biogenic amines and neuropeptides, which requires the Rab27/AEX-6 dense-core vesicle exocytosis machinery; a BBS-8::GFP translational fusion is expressed exclusively in ciliated head and tail neurons, where it localizes predominantly to the base of cilia, known as the ciliary transition zone; bbs gene expression is regulated by the DAF-19 RFX-type transcription factor.

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