Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.

Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Jun, Jun-B and Jun-D) proteins to upregulate ARE-mediated expression ...
and coordinated induction of detoxifying enzymes in response to antioxidants and xenobiotics. Nrf-Jun association/heterodimerization and binding to the ARE required unknown cytosolic factor(s). Nrf2 containing one mutated leucine in its leucine zipper region was more efficient in upregulation of ARE-mediated gene expression, as compared to Nrf1 with two mutated leucines.
Mesh Terms:
Amino Acid Sequence, Animals, Antioxidants, Binding Sites, Collagenases, DNA-Binding Proteins, Gene Expression Regulation, Glutathione Transferase, Humans, Leucine Zippers, Molecular Sequence Data, NAD(P)H Dehydrogenase (Quinone), NF-E2-Related Factor 1, NF-E2-Related Factor 2, Nuclear Respiratory Factor 1, Nuclear Respiratory Factors, Proto-Oncogene Proteins c-fos, Proto-Oncogene Proteins c-jun, Rats, Sequence Homology, Amino Acid, Trans-Activators, Tumor Cells, Cultured, beta-Naphthoflavone
Oncogene
Date: Dec. 17, 1998
Download Curated Data For This Publication
5373
Switch View:
  • Interactions 5