Caenorhabditis elegans

TOR-2

CELE_Y37A1B.13, dyt-1, Y37A1B.13
tor-2 encodes a AAA ATPase that, along with TOR-1 and OOC-5, comprise the three C. elegans orthologs of human torsinA; overexpression of TOR-2 in nematodes with polyglutamine repeat-induced protein aggregates indicates that TOR-2 can suppress protein aggregation, suggesting TOR-2 may play a role in regulation of protein folding; in wild-type animals, TOR-2 localizes to the endoplasmic reticulum; in animals containing polyglutamine protein aggregates, TOR-2 localizes to these sites of protein aggregation.

External Database Linkouts

WormBase | Entrez Gene | RefSeq
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