CELE_Y48E1B.7, Y48E1B.7

lin-38 encodes a C2H2-type zinc-finger protein; lin-38 was originally identified as a Class A synthetic multivulval (SynMuv) gene; lin-38(RNAi) results in partially penetrant embryonic lethality, sterility, and protruding vulvae, and null mutations in lin-38 result in larval lethality and sterility; lin-38 transcript levels are diminished by ERI-1, RDE-3, and RRF-2, perhaps through endogenous RNAi; LIN-38 is paralogous to MCD-1, but has no obvious non-nematode orthologs; LIN-38 contains a single central zinc-finger and a C-terminal low-complexity region, but no other recognizable protein domains.

54633

6239