Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity.

Nuclear factor kappaB (NF-kappaB) and the Rel family of proteins are pleiotropic transcription factors that play central roles in the immune and inflammatory responses, as well as apoptosis. Here, we identified a serine/threonine protein phosphatase X (PPX; also called protein phosphatase 4 (PP4)) that specifically associated with c-Rel, NF-kappaB p50, ...
and RelA. The amino acid sequences of human and mouse PPX are 100% identical, and the PPX gene was mapped to human chromosome 16 p11.2. Overexpression of PPX, but not catalytically inactive PPX mutants, stimulated the DNA-binding activity of c-Rel and activated NF-kappaB-mediated transcription. These results suggest that PPX is a novel activator of c-Rel/NF-kappaB.
Mesh Terms:
Animals, Cell Line, Chromosome Mapping, Humans, Mice, Molecular Sequence Data, NF-kappa B, Phosphoprotein Phosphatases, Protein Binding, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-rel, Recombinant Proteins
J. Biol. Chem.
Date: Dec. 11, 1998
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