CELE_Y75B8A.12, bbs-7, Y75B8A.12

osm-12 encodes a protein that is an ortholog to human BBS7; osm-12 along with bbs-8 is required for cilia biogenesis and function, accordingly, osm-12 mutant animals display odorant chemotaxis defects; oms-12 and bbs-8 are required for intraflagellar transport (IFT) and the motility and function of IFT proteins like OSM-5, CHE-11 and CHE-2; in addition to the sensory defects exhibited by bbs mutants, osm-12 and bbs-8 mutants also show reduced body size, developmental delay, and altered roaming, which are rescued by mutations in the guanylate complex GCY-35/GCY-36, suggesting that BBS proteins may regulate cGMP signaling; OSM-12 is expressed exclusively in ciliated sensory neurons, where it localizes predominantly to the base of cilia, known as the ciliary transition zone; DNA sequences upstream of osm-12 contain X box DNA binding sites, suggesting that osm-12 expression may be regulated by the DAF-19 RFX-type transcription factor.

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