CELE_C08H9.5, tkr-1, C08H9.5

old-1 encodes a receptor protein tyrosine kinase; old-1 plays a role in stress resistance and regulation of adult lifespan; Murakami and Johnson showed that old-1 mRNA levels are upregulated in response to stress and in daf-2 and age-1 mutant backgrounds and that overexpression of old-1 in wild-type animals results in extended lifespan and increased resistance to heat and UV irradiation; in contrast, Murphy et al., showed that old-1 expression is downregulated in daf-2 mutants and that old-1(RNAi) in an rrf-3 mutant background slightly extends lifespan; an OLD-1::GFP fusion protein is expressed in the anterior region of worms, in neuronal, hypodermal, and pharyngeal tissues, as well as in the proximal region of the male gonad; expression is visible in young adults and appears to increase as animals age and in response to heat, starvation, or UV irradiation.

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