Caenorhabditis elegans
PMK-1
CELE_B0218.3, B0218.3
pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289); PMK-1 is an essential component of the MAPK pathway that regulates the innate immune response; PMK-1 is required, upstream of CED-9, for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 physically interacts with the ATF-7 transcription factor to regulate the transcriptional innate immune response and phosphorylation of ATF-7 is dependent upon PMK-1 and SEK-1.
GO Process (16)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- defense response [IMP]
- defense response to Gram-negative bacterium [IMP]
- defense response to Gram-positive bacterium [IMP]
- hyperosmotic response [IGI]
- innate immune response [IMP]
- intracellular signal transduction [IDA]
- p38MAPK cascade [IEP, IMP]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium [IMP]
- programmed cell death [IMP]
- protein phosphorylation [IDA]
- response to osmotic stress [IDA]
- response to reactive oxygen species [IEP]
- response to superoxide [IEP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
56238
6239
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- Interactors 33
- Interactions 34
- Network